Hello, guys

The response variable is average daily dose. I measured it at two time points, that during week 1 and during week 1 later. At first glance I shall use paired-t test. However, beside the group difference of time (week 1 vs. week 1 later), there are other difference, which must be adjusted. So I thought if linear regression could be used to fix my issue. But, independent observations is a requirement for linear regression. So what to do?

Tom