Dear all
I am working on a diagnostic test accuracy review that includes 12 studies reporting the sensitivity and specificity of a test for detection of infection in children (tp,fp,tn and fn for each study enclosed in the excel sheet)
Since each study has reported the diagnostic test estimates at a different threshold value, we needed to obtain the pooled estimates of sensitivity using a HSROC model,
This model cannot be directly fitted in Stata. So, i employed a Bayesian algorithm to obtain a) the five parameters of the HSROC model and then b) summary estimates of sensitivity and specificity. ( model and Bayesian algorithm attached)
What i have got, is the jointly estimated sensitivity and specificity.
Considering that each study has used a different test threshold , i am required to report the pooled sensitivity for a fixed specificity ( median specificity of the 12 studies). and i am unable to get that? Guidance at this step would be greatly appreciated
Thanks
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