Hi all.

I would like to conduct the analysis of a trial comparing two drugs (A and B) on reducing pain associated with a procedure.

Subjects are randomly exposed to either drug A or B then undergo a procedure and asked to score the pain associated with that procedure 0-10. After a washout period, they are exposed to drug B or A (the one they were not initially exposed to) and then undergo the same procedure, again being asked to score their pain 0-10. Subjects are also asked to score their satisfaction with each drug, again on score 0-10. Subjects are also asked to state their overall preference (drug A or B).

Although I can find resources on crossover trials (such as the textbook by Senn 2002, as well as some online explanations of crossover trials), I am unable to find a decent resource with regard to the analysis of one in Stata.

Using "help pkcross" provides some information, but is somewhat brief.

Can anyone help? Indeed, can pkcross be used for experiments such as this or is it more designed for pharmacokinetic experiments as the name suggests?

Regards