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Sunday, November 6, 2022
sample size calculation when there are three groups
Hi,
We are planning to conduct an RCT comparing nitroglycerine patches to decrease the failure rates of radial arterial cannulation. Based on our audit, we expect a 30% failure rate in the placebo arm. We hypothesize that the NTG patch applied for 30 or 45 minutes could reduce the incidence of failure rate by 30%, which corresponds to a 9% absolute risk difference. We want to assume a type I error of 5% and aim for a power of 80%. How much sample size is needed per group?
Since there are three independent groups (placebo, NTG for 30 minutes, NTG for 45 minutes), I am unable to calculate it on Stata.
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